姓名：怀其勇

学历：南开大学理学硕士、博士

职务：副教授，硕士生导师

联系方式：电子邮箱为huaiqy06@sdu.edu.cn

学术兼职：山东省禁化武履约工作专家

科研方向：课题组开展天然化合物的分子修饰及其抗肿瘤活性的研究，主要是设计合成甘草次酸和姜黄素的新型衍生物，并通过MTT法考查其抗癌活性，目的是获得高效低毒的抗癌前药，进而深入研究药物的作用机理和作用靶点，对中药发展和新药开发具有重要作用。

现阶段科研项目：

1.山东省自然科学基金面上项目《抗生物附着活性原花青素类天然产物的合成研究》。

2.山东省重点研发计划项目《甘草次酸衍生物取代吉非替尼前药的研发》。

3.靶向性多功能抗癌活性三萜类衍生物前药的研发。

论文与专利：

1. Synthesis and Evaluation of a Ferrocene-Bonded Silica Phase for RP-HPLC，Q.Y.Huai, X.L.wang, Y.M.Zuo, Chromatographia, 2002, 55(9/10): 549-553.

2. Evaluation of the Retention Characteristics of Ferrocene-bonded Silica Reversed Phases for HPLC Using Linear Solvation Energy Relationships，Q.Y. Huai, J.M.You, Q. wang and Y. M. Zuo, Chromatographia, 2003, 57 (11/12): 709-713.

3. Preparation and Evaluation of an End-Capped p-tret-Butyl-Calix[4]arene-Bonded-Silica Stationary Phase for RP-HPLC，Q.Y. Huai, B. Zhao, Y.M. Zuo, Chromatographia, 2004, 59 (9/10): 637-645.

4. Study of the Retention Characteristics of Calix[4]arene-bonded Silica Stationary Phase and Comparison with Common Phases for HPLC Using Linear Solvation Energy Relationships，Q.Y. Huai, Y.M. Zuo, Journal of Liquid Chromatography & Related Technologies, 2006, 29:799-812.

5. 对-叔丁基-杯[4]芳烃键合硅胶固定相以及其它硅胶基质键合固定相的色谱保留性质，怀其勇,左育民,分析化学, 2006,34(7):919 - 922.

6. Synthesis of Porous Titaniaspheres for HPLC by Polymerization-Induced Colloid Aggregation (PICA) Using tert-n-Butyl Titanate，Q.Y. Huai, Y.M. Zuo, Journal of Analytical Chemistry，2009, 64(2):169-173.

7. Synthesis and antimicrobial activities on Staphylicoccus aureus of miscellaneous atomic curcumin derivatives，Huasen Wang,Qiyong Huai^*,Asian Journal of Chemistry，Volume 25 (2013)，9:4836-4839.

8. Synthesis and electrochemical properties of ferrocene formylated curcumin，Xiushang Xu, Lingkai Kong,Qiyong Huai^*,Asian Journal of Chemistry,Volume 25 (2013)，13:7637-7638.

9. Fast detection of saxitoxin using laser tweezers surfaceenhanced Raman spectroscopy，Qi-yong Huai, Chun-lei Gao,Jin-lai Miao, Hui-lu Yao and Zong-ling Wang，Analytical Methods，2013,5,6870–6873.

10. Synthesis and Properties of Copper(II)-Ferrocene Formylated Curcumin，Qiyong Huai, JunqiangYU,Xiushang Xu, Jinlai Miao, Zongling Wang,Asian Journal of Chemistry，Volume 26 (2014)，1:261-263.

11. Anti-Allergic and Antioxidant Effects of Flavonoid Glycosides Isolated from Hop (Humulus lupulus L) Flowers，Yang Li, Hua Yin, Zhonghua Qian, Jinlai Miao andQiyong Huai*，Asian Journal of Chemistry，Volume26(2014)，10:3061-3063.

12. Synthesis and Performance of Ferrocene-BondedChiral Stationary Phase forRP-HPLC，Huijing Li, Zhifang Song, Junqiang Yu, Yang Li, Ling Feng andQiyong Huai*，AsianJournal ofChemistry，Volume 26(2014)，14：4465-4468.

13. Synthesis and Biological Evaluation of Novel Curcuminoids Derivatives，Yakun Cao, huijing Li, zhifang Song, yang Li,Qiyong Huai *，Molecules，2014，19：16349-16372.

14. Synthesis and Evaluation of Antibacterial and Antitumor Activities of Apigenin Derivatives，Ling Feng, Ya-Kun Cao, Yang Li, Zhi-Fang Song andQi-Yong Huai*，Asian Journal of Chemistry，Volume27(2015)，8:2830-2832.

15. Rearrangement of Dypnones to 1,3,5-Triarylbenzenes,Kai Deng^§,Qi-Yong Huai^§, Zhi-Lun Shen,Hui-Jing Li,Chen Liu,and Yan-Chao Wu,Organic Letters,2015, 17:1473−1476.

16. Synthesis and Biological Evaluation of Curcuminoid Derivatives，Ling Feng,Yang Li,Zhi-fang Song,Hui-jing Li,andQi-yong Huai*,Chemicaland Pharmaceutical Bulletin,2015，63：873–881.

17. Synthesis and anticanceractivitiesofGlycyrrhetinicAcid Derivatives，Yang Li , Ling Feng , Zhi-Fang Song , Hai-Bei Li andQi-Yong Huai*，Molecules，2016，21(2), 199-218.

18. Design and Synthesis of New Anticancer Glycyrrhetinic Acids and Oleanolic Acids,Rui Wang, Qing-xuan Zheng,Wei Wang,Ling Feng,Hui-jing Li, andQi-yong Huai*,Biological and Pharmaceutical Bulletin,2017, 40(5):703-710.

19. Efficient Synthesis of Functionalized 4H-Chromenes via an Fe(OTf)3-Catalyzed Cyclization Reaction of Phenols and Ketones,Kai Deng,Qi-Yong Huai,Hui-Jing Li,Jun-Hu Wang,Hui-Ru Yang,Ying Liu,Yan-Chao Wu, Synthesis,2018,50, 1482–1492.

20. Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties, Rui Wang,Yang Li,Xu-Dong Huai,Qing-Xuan Zheng,Wei Wang,Hui-Jing Li,Qi-Yong Huai*,Drug Design, Development and Therapy,2018,12:1321–1336.

21. Design and synthesis of the novel oleanolic acid-cinnamic acid esterderivatives and glycyrrhetinic acid-cinnamic acid ester derivatives withcytotoxic properties,Rui Wang, Wei Yang, Yiqing Fan, Wim Dehaen, Yang Li, Huijing Li, Wei Wang,Qingxuan Zheng,Qi-Yong Huai*,Bioorganic Chemistry,2019 (88) 102951:1–15.

22. Design, Preparation and Studies Regarding Cytotoxic Properties ofGlycyrrhetinic Acid Derivatives,Qing-Xuan Zheng,Rui Wang,Yan Xu,Chang-Xin He,Cai -Yun Zhao,Zhi-Fang Wang,Rui Zhang,Wim Dehaen,Hui-Jing Li,andQi-Yong Huai*,Biological and Pharmaceutical Bulletin, 2020, 43(1): 102-109.

23. Synthesis and discovery of mitochondria-targeting oleanolic acid derivatives for potential PI3K inhibition,YiLi,QingqingZeng,RuiWang,BoWang,RuofanChen,NaWang,YiruLu,FangwenShi,WimDehaen,Qi-Yong Huai*,Fitoterapia, 2022,( 162): 105291.

24. Design,preparationandstudiesregardingcytotoxicpropertiesofbenzyloleanates,Qing-Xuan Zheng, Rui Wang, Hui-Jing Li, Wim Dehaen, Qi-Yong Huai1*,Pharmaceutical Chemistry Journal, 2023,57(8) : 1210-1214.

25.  

26. 辛伐他仃的鉴定与分析

    杨俊佼,怀其勇,陈启发,左育民,分析化学,2001,29(11):1254-1258

27. 高效液相色谱-串联质谱法鉴定伊维菌素的成分

    雷荣,马丽娟,怀其勇,左育民,分析化学,2002,30(1):26-30

28. 一种制备无纺布专用乳胶漆的方法

    怀其勇，马庆林,中华人民共和国发明专利，专利号ZL 201010280333.6

29. 一种活性姜黄素衍生物及其制备方法

    怀其勇，马庆林,中华人民共和国发明专利，专利号ZL 201210525212.2

30. 4,6-双芳氧基嘧啶衍生物及其合成方法和应用

    怀其勇，徐岩,中华人民共和国发明专利，专利号ZL 202110573387.X

31. 磺酰胺类18-β甘草次酸衍生物及其制备方法和应用

    怀其勇，李伊,中华人民共和国发明专利，专利号ZL 202111094386.3

    30.南非发明专利

    a.SULFONAMIDE 18 BETA-GLYCRRHETINIC ACID DERIVATIVE AND PREPARATION METHOD AND USE THEREOF

    怀其勇，李伊，专利号ZA2022/01862

    b.COMPOSITE NANO-TiO2 AND ZnO WATERBORNE EPOXY RESIN FLOOR SURFACE PAINT AND PREPARATION METHOD THEREOF

    怀其勇，马庆林，专利号ZA2022/02144

    c.4,6-BISARYLOXYPYRIMIDINE DERIVATIVE, SYNTHESIS METHOD AND APPLICATION THEREOF

    怀其勇，徐岩，专利号ZA2022/03321

    d.OLEANOLIC ACID DERIVATIVE AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF

    怀其勇，曾清清，专利号ZA2022/03324